People

Stephen J. Kron, MD PhD

The Kron laboratory is a diverse and collaborative group of cell biologists, geneticists, biochemists, chemists and computer scientists. Our current basic research and technology efforts include 1) defining roles for chromatin dynamics and cell cycle regulation in DNA damage checkpoint response and cellular senescence, 2) dissecting cross-talk between metabolism and DNA damage response, 3) developing novel molecular assays to interrogate cell signaling in cancer, and 4) implementing novel mass spectrometry approaches to enable quantitative proteomics. We also pursue translational projects directed at 1) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization, 2) examining DNA damage and repair in tissues and tumors, and 3) exploiting DNA damage responses to induce anti-tumor immune responses.

Whitehead Institute
Cambridge MA
- Genetics
1995

Stanford University
Stanford CA
PhD - Cell Biology
1990

Stanford University
Stanford CA
MD - Medicine
1990

University of Pennsylvania
Philadelphia PA
MSE - Bioengineering
1983

University of Pennsylvania
Philadelphia PA
BA - Biochemistry
1982

Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells.
Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells. J Immunother Cancer. 2023 02; 11(2).
PMID: 36792123

Epidermal stratification requires retromer-mediated desmoglein-1 recycling.
Epidermal stratification requires retromer-mediated desmoglein-1 recycling. Dev Cell. 2022 12 19; 57(24):2683-2698.e8.
PMID: 36495876

Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization.
Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization. Cell Chem Biol. 2022 10 20; 29(10):1517-1531.e7.
PMID: 36206753

Far-red Fluorescent Senescence-associated ?-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry.
Far-red Fluorescent Senescence-associated ?-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry. J Vis Exp. 2022 09 13; (187).
PMID: 36190263

Loss of MEN1 function impairs DNA repair capability of pancreatic neuroendocrine tumors.
Loss of MEN1 function impairs DNA repair capability of pancreatic neuroendocrine tumors. Endocr Relat Cancer. 2022 03 21; 29(4):225-239.
PMID: 35171113

Genomic studies controvert the existence of the CUX1 p75 isoform.
Genomic studies controvert the existence of the CUX1 p75 isoform. Sci Rep. 2022 01 07; 12(1):151.
PMID: 34997000

TdT-dUTP DSB End Labeling (TUDEL), for Specific, Direct In Situ Labeling of DNA Double Strand Breaks.
TdT-dUTP DSB End Labeling (TUDEL), for Specific, Direct In Situ Labeling of DNA Double Strand Breaks. Methods Mol Biol. 2022; 2394:299-317.
PMID: 35094335

Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response.
Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response. Cell Rep. 2021 11 16; 37(7):110004.
PMID: 34788624

Pseudomonas syringae effector HopZ3 suppresses the bacterial AvrPto1-tomato PTO immune complex via acetylation.
Pseudomonas syringae effector HopZ3 suppresses the bacterial AvrPto1-tomato PTO immune complex via acetylation. PLoS Pathog. 2021 11; 17(11):e1010017.
PMID: 34724007

Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy.
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy. J Natl Cancer Inst. 2021 10 01; 113(10):1285-1298.
PMID: 33792717

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