People

Michael J. Rust, PhD

Bacteria are an ancient form of life that occupies almost every conceivable niche, from pathogenesis to commensal existence with an animal host to primary production in oceans and lake. Despite their apparent simplicity, bacteria possess sophisticated biochemical networks that dynamically store information about the size and status of the cell and conditions in the external environment. These biochemical systems allow precise decision making that allow microbes to thrive in challenging conditions. Our lab is interested in the design principles of these reaction networks. We use a multidisciplinary approach: biochemical reconstitution of the underlying interactions, single cell microscopy to study function, and mathematical modeling to rebuild systems in silico. A major focus area is bacterial circadian rhythms, which allow single cells to predict the time of day.

The circadian clock ensures successful DNA replication in cyanobacteria.
Liao Y, Rust MJ. The circadian clock ensures successful DNA replication in cyanobacteria. Proc Natl Acad Sci U S A. 2021 May 18; 118(20).
PMID: 33972427

Roadmap on biology in time varying environments.
Murugan A, Husain K, Rust MJ, Hepler C, Bass J, Pietsch JMJ, Swain PS, Jena SG, Toettcher JE, Chakraborty AK, Sprenger KG, Mora T, Walczak AM, Rivoire O, Wang S, Wood KB, Skanata A, Kussell E, Ranganathan R, Shih HY, Goldenfeld N. Roadmap on biology in time varying environments. Phys Biol. 2021 May 17; 18(4).
PMID: 33477124

Daily Cycles of Reversible Protein Condensation in Cyanobacteria.
Pattanayak GK, Liao Y, Wallace EWJ, Budnik B, Drummond DA, Rust MJ. Daily Cycles of Reversible Protein Condensation in Cyanobacteria. Cell Rep. 2020 08 18; 32(7):108032.
PMID: 32814039

Bayesian modeling reveals metabolite-dependent ultrasensitivity in the cyanobacterial circadian clock.
Hong L, Lavrentovich DO, Chavan A, Leypunskiy E, Li E, Matthews C, LiWang A, Rust MJ, Dinner AR. Bayesian modeling reveals metabolite-dependent ultrasensitivity in the cyanobacterial circadian clock. Mol Syst Biol. 2020 06; 16(6):e9355.
PMID: 32496641

Kalman-like Self-Tuned Sensitivity in Biophysical Sensing.
Husain K, Pittayakanchit W, Pattanayak G, Rust MJ, Murugan A. Kalman-like Self-Tuned Sensitivity in Biophysical Sensing. Cell Syst. 2019 Nov 27; 9(5):459-465.e6.
PMID: 31563474

Molecular dynamics simulations of nucleotide release from the circadian clock protein KaiC reveal atomic-resolution functional insights.
Hong L, Vani BP, Thiede EH, Rust MJ, Dinner AR. Molecular dynamics simulations of nucleotide release from the circadian clock protein KaiC reveal atomic-resolution functional insights. Proc Natl Acad Sci U S A. 2018 12 04; 115(49):E11475-E11484.
PMID: 30442665

Geographically Resolved Rhythms in Twitter Use Reveal Social Pressures on Daily Activity Patterns.
Leypunskiy E, Kiciman E, Shah M, Walch OJ, Rzhetsky A, Dinner AR, Rust MJ. Geographically Resolved Rhythms in Twitter Use Reveal Social Pressures on Daily Activity Patterns. Curr Biol. 2018 12 03; 28(23):3763-3775.e5.
PMID: 30449672

The Min Oscillator Defines Sites of Asymmetric Cell Division in Cyanobacteria during Stress Recovery.
Liao Y, Rust MJ. The Min Oscillator Defines Sites of Asymmetric Cell Division in Cyanobacteria during Stress Recovery. Cell Syst. 2018 11 28; 7(5):471-481.e6.
PMID: 30414921

High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock.
Chew J, Leypunskiy E, Lin J, Murugan A, Rust MJ. High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock. Nat Commun. 2018 08 01; 9(1):3004.
PMID: 30068980

Biophysical clocks face a trade-off between internal and external noise resistance.
Pittayakanchit W, Lu Z, Chew J, Rust MJ, Murugan A. Biophysical clocks face a trade-off between internal and external noise resistance. Elife. 2018 07 10; 7.
PMID: 29988019

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Pew Scholar
2014 - 2018