People

Sampriti Mukherjee, PhD

Our overarching goal is to understand how bacteria decode and integrate self-generated and environmentally-derived stimuli to control transitions between individual and collective behaviors. Bacterial responses to self-generated and exogenous stimuli influence their survival, persistence in particular niches, and lifestyle transitions, such as alterations between being free-swimming (individual behavior) or existing in structured antibiotic-resistant communities called biofilms (collective behavior). How the information encoded in multiple sensory inputs is extracted and integrated to drive transitions between individual and collective behaviors is largely mysterious. We use bacterial genetics, molecular biology, biochemistry, microfluidics, fluorescence microscopy, and genome-scale studies to study fundamental questions about bacterial signal detection, signal relay, signal integration, and the consequences to collective behaviors. Ultimately, understanding how information encoded in diverse sensory inputs drives collective behaviors will be foundational for designing successful synthetic strategies to enhance or to inhibit biofilms and for developing novel therapeutic interventions.

Princeton University
Princeton, NJ , USA
Postdoctoral Fellow - Molecular Biology
2020

Indiana University
Bloomington, IN, USA
PhD - Microbiology
2014

University of Calcutta
Kolkata, India
MS - Microbiology
2009

University of Calcutta
Kolkata, India
BS - Microbiology
2007

Searching for the Secret of Stickiness: How Biofilms Adhere to Surfaces.
Jiang Z, Nero T, Mukherjee S, Olson R, Yan J. Searching for the Secret of Stickiness: How Biofilms Adhere to Surfaces. Front Microbiol. 2021; 12:686793.
PMID: 34305846

Another battle won in the phage-host arms race: Pseudomonas phage blocks quorum sensing regulator LasR.
van Kessel JC, Mukherjee S. Another battle won in the phage-host arms race: Pseudomonas phage blocks quorum sensing regulator LasR. Mol Cell. 2021 02 04; 81(3):420-422.
PMID: 33545057

Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors.
Mukherjee S, Jemielita M, Stergioula V, Tikhonov M, Bassler BL. Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors. PLoS Biol. 2019 12; 17(12):e3000579.
PMID: 31830037

Bacterial quorum sensing in complex and dynamically changing environments.
Mukherjee S, Bassler BL. Bacterial quorum sensing in complex and dynamically changing environments. Nat Rev Microbiol. 2019 06; 17(6):371-382.
PMID: 30944413

Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling.
Yan J, Moreau A, Khodaparast S, Perazzo A, Feng J, Fei C, Mao S, Mukherjee S, Košmrlj A, Wingreen NS, Bassler BL, Stone HA. Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling. Adv Mater. 2019 01; 31(4):e1807586.
PMID: 30667139

Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling.
Yan J, Moreau A, Khodaparast S, Perazzo A, Feng J, Fei C, Mao S, Mukherjee S, Košmrlj A, Wingreen NS, Bassler BL, Stone HA. Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling. . 2019 01; 31(4):e1807586.
PMID: 30667139

Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling.
Yan J, Moreau A, Khodaparast S, Perazzo A, Feng J, Fei C, Mao S, Mukherjee S, Košmrlj A, Wingreen NS, Bassler BL, Stone HA. Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling. . 2018 Nov; 30(46):e1804153.
PMID: 30368924

Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling.
Yan J, Moreau A, Khodaparast S, Perazzo A, Feng J, Fei C, Mao S, Mukherjee S, Košmrlj A, Wingreen NS, Bassler BL, Stone HA. Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling. Adv Mater. 2018 Nov; 30(46):e1804153.
PMID: 30368924

The PqsE and RhlR proteins are an autoinducer synthase-receptor pair that control virulence and biofilm development in Pseudomonas aeruginosa.
Mukherjee S, Moustafa DA, Stergioula V, Smith CD, Goldberg JB, Bassler BL. The PqsE and RhlR proteins are an autoinducer synthase-receptor pair that control virulence and biofilm development in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):E9411-E9418.
PMID: 30224496

FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis.
Altegoer F, Mukherjee S, Steinchen W, Bedrunka P, Linne U, Kearns DB, Bange G. FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis. Sci Rep. 2018 08 01; 8(1):11552.
PMID: 30068950

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NIH Pathway to Independence Award (K99/R00)
2018 - 2023

Life Sciences Research Foundation Postdoctoral Fellowship
2016 - 2019