The Fehon laboratory studies the organization and function of signaling pathway components at the cell cortex, particularly relating to the Hippo growth control pathway. In addition to their known role in organizing receptors and downstream effectors into functional signaling complexes, such organized complexes function to integrate signaling activities from multiple pathways and to segregate simultaneous but distinct functions of a single pathway. We study this question in Drosophila because of the utility of this system for studying the functions of individual genes, and for examining the functional interactions between different genes that work together in a particular cellular or developmental process.
Yale University
New Haven, CT
Postdoctoral - Developmental Genetics
1991
University of Washington
Seattle, WA
PhD - Developmental Biology
1986
Duke University
Durham, NC
BS - Zoology
1980
Upstream Regulation of the Hippo Pathway.
Upstream Regulation of the Hippo Pathway. Cold Spring Harb Perspect Biol. 2026 Sep 04.
PMID: 42697693
aPKC and F-actin dynamics promote Hippo pathway polarity in asymmetrically dividing neuroblasts.
aPKC and F-actin dynamics promote Hippo pathway polarity in asymmetrically dividing neuroblasts. Biol Open. 2026 Mar 15; 15(3).
PMID: 41641588
Fat and Dachsous Signaling-Controlling Growth Requires Both Competition and Cooperation: Competitive Interactions at the Cell Cortex Restrict the Ability of an Unusual Protein Complex to Promote Tissue Growth.
Fat and Dachsous Signaling-Controlling Growth Requires Both Competition and Cooperation: Competitive Interactions at the Cell Cortex Restrict the Ability of an Unusual Protein Complex to Promote Tissue Growth. Bioessays. 2026 Jan; 48(1):e70103.
PMID: 41572945
aPKC and F-actin Dynamics Promote Hippo Pathway Polarity in Asymmetrically Dividing Neuroblasts.
aPKC and F-actin Dynamics Promote Hippo Pathway Polarity in Asymmetrically Dividing Neuroblasts. bioRxiv. 2025 Nov 06.
PMID: 41279835
Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth.
Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth. J Cell Biol. 2024 12 02; 223(12).
PMID: 39373700
Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth.
Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth. bioRxiv. 2024 Aug 28.
PMID: 38948705
Yellow and oxidation-resistant derivatives of a monomeric superfolder GFP.
Yellow and oxidation-resistant derivatives of a monomeric superfolder GFP. Mol Biol Cell. 2024 Oct 01; 35(10):mr8.
PMID: 39141403
Yellow and oxidation-resistant derivatives of a monomeric superfolder GFP.
Yellow and oxidation-resistant derivatives of a monomeric superfolder GFP. bioRxiv. 2024 Jan 26.
PMID: 38328041
Cortical tension promotes Kibra degradation via Par-1.
Cortical tension promotes Kibra degradation via Par-1. Mol Biol Cell. 2024 01 01; 35(1):ar2.
PMID: 37903240
Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling.
Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling. Dev Cell. 2023 10 09; 58(19):1864-1879.e4.
PMID: 37729921