Research Summary

The Kron laboratory is a highly collaborative group of cell biologists, geneticists, biochemists, chemists and computer scientists. Our major basic research and technology efforts are directed at 1) defining roles for chromatin modifications and cell cycle regulators in DNA damage checkpoint response and 2) developing novel mass spectrometry approaches for quantitative phosphoproteomics. We also pursue translational projects directed at 1) developing assays for leukemia diagnostics and therapeutic monitoring and 2) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization.

Attention: Post-doc inquiries welcomed. Please, contact Dr. Kron at

Selected Publications

Tobe BT, Kitazono AA, Garcia JS, Gerber RA, Bevis BJ, Choy JS, Chasman D, Kron SJ. (2009) "Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase." Cell Div., 4:12. (PubMed)

S.L. Volchenboum, K. Kristjansdottir, D. Wolfgeher, and S.J. Kron (2009). "Rapid validation of Mascot search results via stable isotope labeling, pair picking, and deconvolution of fragmentation patterns," Mol. Cell. Proteomics [Epub ahead of print]. (PubMed)

Kristjansdottir K, Wolfgeher D, Lucius N, Angulo DS, Kron SJ. (2008). "Phosphoprotein profiling by PA-GeLC-MS/MS," J. Proteome Research, 7:2812-2824. (PubMed)

Ulanovskaya OA, Janjic J, Suzuki M, Sabharwal SS, Schumacker PT, Kron SJ, Kozmin SA. (2008). "Chemical synthesis enables identification of cytochrome bc1 complex as the cellular target of Leucascandrolide A and Neopeltolide," Nature Chem. Biol., 4:418-24. (PubMed)

Wu, D., Mand, M.R., Veach, D.R., Parker, L.L., Clarkson, B. and Kron, S.J. (2008). "A solid-phase Bcr-Abl kinase assay in 96-well hydrogel plates." Anal Biochem 375:18-26. (PubMed)

Bickenbach, K.A., Veerapong, J., Shao, M.Y., Mauceri, H.J., Posner, M.C., Kron, S.J. and Weichselbaum, R.R. (2008). "Resveratrol is an effective inducer of CArG-driven TNF-alpha gene therapy." Cancer Gene Ther 15:133-9. (PubMed)

Parker, L., Engel-Hall, A., Drew, K., Steinhardt, G., Helseth, Jr. D.L., Jabon, D., McMurry, T., Angulo, D.S. and Kron, S.J. (2008). "Investigating quantitation of phosphorylation using MALDI-TOF mass spectrometry." J Mass Spectrom 43:518-527. (PubMed)

McSherry, T.D., Kitazono, A.A., Javaheri, A., Kron, S.J. and Mueller, P.R. (2007). "Non-catalytic function for ATR in the checkpoint response." Cell Cycle 6:2019-30. (PubMed)

Wysocki, R., Javaheri, A., Kristjansdottir, K., Sha, F. and Kron, S. J. (2006). "CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage." Nat Struct Mol Biol 13:908-914. (PubMed)

Javaheri, A., Wysocki, R., Jobin-Robitaille, O., Altaf, M., Cote, J. and Kron, S. J. (2006). "Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling." Proc Natl Acad Sci U S A 103:13771-6. (PubMed)

Parker, L. L., Kurutz, J. W., Kent, S. B. and Kron, S. J. (2006). "Control of the yeast cell cycle with a photocleavable alpha-factor analogue." Angew Chem Int Ed Engl 45:6322-5. (PubMed)