Richard Fehon, PhD
Membrane organization and signaling

Chairman, Molecular Genetics and Cell Biology, Professor, Molecular Genetics and Cell Biology, Committee on Cancer Biology,
Committee on Development, Regeneration, and Stem Cell Biology, Committee on Genetics, Genomics & Systems Biology

B.S., Zoology, Duke University, 1980
Ph.D., Zoology, University of Washington, 1986

 

Research Summary

Our interests center on the molecular mechanisms by which signal transduction pathways are organized into specialized membrane domains. In addition to their known role in organizing receptors and downstream effectors into functional signaling complexes, such organized complexes function to integrate signaling activities from multiple pathways and to segregate simultaneous but distinct functions of a single pathway. We study this question in Drosophila because of the utility of this system for studying the functions of individual genes via mutagenesis, and for examining the functional interactions between different genes that work together in a particular cellular or developmental process.


Selected Publications

Boggiano, J.C and Fehon, R.G. Growth control by committee: Intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signaling. Dev. Cell. 2012 22: 695-702. (PubMed)

Boggiano, J.C, Vanderzalm, P.J. and Fehon, R.G. Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. Dev. Cell. 2011 21:888-895. (PubMed)

Oshima, K. and Fehon, R.G. Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs Large. J. Cell Sci. 2011 124: 2861-71. (PubMed)

Neisch, A.L., Speck, O., Stronach, B., and Fehon, R.G. Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. J. Cell Biol. 2010 189: 311-23. (PubMed)

Nilton, A., Oshima, K., Zare, F., Byri, S., Nannmark, U., Nyberg, K.G., Fehon, R.G., and Uv, A.E. Crooked, Coiled and Crimpled are three Ly6-like proteins required for proper localization of septate junction components. Development. 2010 137: 2427-37. (PubMed)

Fehon, RG, McClatchey, AI, and Bretscher, A. Organizing the Cell Cortex: The role of ERM proteins. Nat. Rev. Mol. Cell Biol. 2010 11: 276-287. (PubMed)

Li Q, Nance MR, Kulikauskas R, Nyberg K, Fehon R, Karplus PA, Bretscher A, and Tesmer J. Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain. J Mol Biol. 2007 365:1446-59. (PubMed)

Hughes SC, and Fehon RG. Phosphorylation and activity of the tumor-suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase. J. Cell Biol. 2006 175:305-13. (PubMed)

Maitra S, Kulikauskas RM, Gavilan H, Fehon RG. The tumor suppressors Merlin and expanded function cooperatively to modulate receptor endocytosis and signaling. Curr Biol. 2006 Apr 4;16(7):702-9. (PubMed)

Speck O, Hughes SC, Noren NK, Kulikauskas RM, Fehon RG. Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity. Nature. 2003 421:83-7. (PubMed)

 

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